Beta-Catenin and PS1
caspase mediated cleavage of PS1 (at a.a. 329 and 341) during apoptosis (Tesco, et al., 1998). FAD
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Protofibrillar Aβ in Alzheimer's Disease
Dean? William Klein: Let me start by saying how much I enjoyed the paper by Dean et al. A good read.
Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein
the Danish and British dementia ? Ben: BDI, Huntington's, Parkinson's, ALS, etc. So MANY
New Theories of Presenilin Function
phosphorylation and subsequent degradation of beta-catenin (Takashima et al., 1998; Zhang et al., 1998). Niwa
The Role of ApoE in Alzheimer's Disease: An Alternative View
periphery. See (Shibata et al. 2000, Demeester et al. 2000, Rebeck et al. 1998, Koudinov et al., 2002.)
Neural Stem Cells to the Rescue—Can Neuroreplacement Ever Become a Treatment for Alzheimer's?
subsequent improvement of cognitive function (Qu et al., 2001) reinforces the potential feasibility of HNSC
Alzheimer Genes in Cortical Development: How Do Their Prenatal Functions Relate to Dementia?
Mice lacking both PS1 and PS2 die before embryonic day 9 (Donoviel et al., 1999). PS1-/- mice, which
From Here to There: AβPP as an Axonal Transport Receptor—How Could This Explain Neurodegeneration in AD?
Ashford, Soultanian, et al., 1999. We did not examine axons. However, this discussion seems to be focusing
CAA: We All Know It's There, But Just What Is It Doing in Alzheimer's?
al., 2000; Weller et al., 1998). Moreover, in transgenic mice, virtually identical amyloid-associated
RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?
1992; Cogoni et al., 1996). Since its first description in animal cells (Fire et al., 1998), a growing
Cholinergic Plasticity in Hippocampus of Individuals with Mild Cognitive Impairment: Correlation with Alzheimer's Neuropathology
caused the sprouting. See our paper in J Neuroscience in November (Sheng et al., 2002). Milos Ikonomovic
Therapeutic Nihilism: Widespread Yet Passé? AD Acetylcholinesterase Inhibitors Are Better Than Their Reputation
need such a lesson and do have to depart). Pete Nelson Thanks for the chat, Gabrielle et al.; it was
Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?
See Harrison et al., 2003.] Stefan Lichtenthaler Gabrielle, this brings us to the question of
Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?
Indirect evidence is there. APP translation is regulated by iron (Rogers et al., 2002). Alexei Koudinov
Stem Cell Therapies for Neurodegenerative Disease: How Should We Push Ahead?
One was from my colleague Chuck Murry (see Murry et al., 2004), and the other involved Irv Weissman
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